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Abstract
Fisetin selectively induces apoptosis in senescent human umbilical vein endothelial cells (HUVECs).
- Senescent cells accumulate with aging and chronic diseases.
- Senolytics are drugs that promote the death of senescent cells by disabling their survival mechanisms.
- Fisetin, A1331852, and A1155463 are identified as senolytic agents with potential advantages over existing options.
- Fisetin induces cell death in senescent HUVECs but does not affect senescent IMR90 cells or primary human preadipocytes.
- A1331852 and A1155463 are effective in both HUVECs and IMR90 cells, but not in preadipocytes.
- These agents may present fewer toxicity concerns compared to navitoclax, particularly regarding hematological effects.
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