New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Fisetin selectively induces apoptosis in senescent human umbilical vein endothelial cells (HUVECs).

• Senescent cells accumulate with aging and chronic diseases.
• Senolytics are drugs that promote the death of senescent cells by disabling their survival mechanisms.
• Fisetin, A1331852, and A1155463 are identified as senolytic agents with potential advantages over existing options.
• Fisetin induces cell death in senescent HUVECs but does not affect senescent IMR90 cells or primary human preadipocytes.
• A1331852 and A1155463 are effective in both HUVECs and IMR90 cells, but not in preadipocytes.
• These agents may present fewer toxicity concerns compared to navitoclax, particularly regarding hematological effects.

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