Full text is available at the source.
Abstract
Senescent cells exhibit a heterogeneous range of phenotypes rather than a uniform state.
- Senescence is characterized by varied biological factors including different markers and cellular origins.
- Technical variations in experimental methods, particularly in transgenic mouse models, contribute to this heterogeneity.
- Recent advancements in senolytic strategies and multiomics profiling help clarify the complexities of senescent cells.
- Understanding the origins and consequences of senescent cell diversity is crucial for improving research methodologies.
- Targeted therapies may be developed to selectively address specific senescent cell populations validated by in vivo studies.
Simplified