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Abstract
Accumulation of senescent endothelial cells may be the primary cause of cardiovascular diseases.
- Endothelial cells play a role in stimulating the immune system and inflammation.
- Ageing leads to deterioration of immune cells and reduced immune response activation.
- This decline could impair the immune system's ability to eliminate damaged or senescent cells.
- Changes in Toll-like receptors and microRNAs may alter the characteristics of senescent endothelial and immune cells.
- A negative feedback loop may exist to limit excessive inflammatory responses in ageing.
- Senescent endothelial cells may influence age-related increases in inflammatory burden.
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