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Senescent‐Like Myofibers Contribute to Anti‐Regenerative Cytokine Signaling in Duchenne Muscular Dystrophy
Aging-like Muscle Fibers May Add to Signals That Block Muscle Repair in Duchenne Muscular Dystrophy
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Abstract
ablation in a rat model of (DMD) significantly improved muscle regeneration.
- p16 expression in skeletal muscles is associated with cellular aging and muscle degeneration in DMD.
- RNA sequencing showed that p16 upregulates cytokine gene expression in DMD rat skeletal muscles.
- Cytokine changes also altered the systemic blood cytokine profile in DMD rats.
- Grafted muscles from wild-type rats had suppressed regeneration in DMD rats, but this was enhanced by p16 ablation.
- Cytokines secreted by aging-like myofibers may contribute to a harmful environment for muscle regeneration in DMD.
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Key numbers
-dependent upregulation
Cytokine Expression Increase
Cytokine levels in rat myofibers are significantly higher than in wild-type.
smaller in rats
Regenerating Myofiber Diameter Decrease
Diameter of regenerating myofibers was lower in rats compared to wild-type or -null rats.