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Abstract
Senescent repair memory may contribute to chronic diseases such as kidney disease and pulmonary fibrosis.
- Tissues can retain a persistent state of failed repair after an initial injury has subsided.
- This state is characterized by ongoing inflammation, fibrosis, and functional decline.
- Strongest evidence for this phenomenon is found in chronic kidney disease, pulmonary fibrosis, and metabolic liver disease.
- Cardiovascular disease and osteoarthritis evidence is primarily based on experimental or associative studies.
- The connection to neurodegeneration is largely indirect and requires further investigation.
- Senescent repair memory is presented as a framework rather than a new molecular pathway, linking unresolved senescence to chronic disease.
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