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Serotonergic activation potentiates light resetting of the main circadian clock and alters clock gene expression in a diurnal rodent
Serotonin boosts light’s ability to reset the body clock and changes clock gene activity in a daytime rodent
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Abstract
Daily serotonin content in the SCN of the diurnal rodent Arvicanthis ansorgei peaks during daytime.
- Injections of the serotonin receptor agonist 8-OH-DPAT induce behavioral phase-advances in nocturnal rodents, correlated with decreased expression of clock genes Per1/2.
- Fluoxetine, a selective serotonin reuptake inhibitor, also reduces light-induced phase-shifts during the subjective night in nocturnal species.
- In contrast, the sensitivity of Arvicanthis SCN to 8-OH-DPAT occurs primarily during the subjective night.
- Fluoxetine administration produces behavioral phase-advances at both circadian time (CT) 0 and CT12 in Arvicanthis.
- Serotonergic activation significantly alters the light responses of specific clock genes at different circadian times.
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