Serotonergic potentiation of dark pulse‐induced phase‐shifting effects at midday in hamsters

May 24, 2008Journal of neurochemistry

Serotonin boosts midday body clock shifts caused by dark pulses in hamsters

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Abstract

Two hours of darkness during subjective day increased serotonin levels in the suprachiasmatic nucleus (SCN) of Syrian hamsters.

  • Darkness at mid-subjective day led to elevated serotonin concentrations in SCN tissue.
  • The expression of c-FOS in the raphe nuclei was induced by dark exposure.
  • Both the 5-HT(1A/7) agonist +8-OH-DPAT and dark pulses caused similar phase-advances in the activity rhythm.
  • Combining the agonist with dark pulses resulted in larger phase-advances than either treatment alone.
  • Pre-treatment with a 5-HT(7) antagonist blocked the phase-shifts induced by darkness, while a 5-HT(1A) antagonist did not.

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