Serotonin 1B receptors on forebrain excitatory neurons may help reduce anxiety after psilocybin in mice

Psilocybin is associated with rapid and sustained antidepressant-like and anxiolytic effects.

• The serotonin 2A receptor is involved in the acute psychedelic effects of psilocybin.
• Psilocin, the active form of psilocybin, interacts with multiple serotonin receptor subtypes.
• Prior findings indicate that the serotonin 1B receptor is necessary for the post-acute effects of psilocybin in mice.
• Serotonin 1B receptors are found in various brain regions on different types of neurons.

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