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Abstract
Psychedelics exert their effects through the serotonergic system by binding to various serotonin receptor subtypes.
- Psychedelics have distinct receptor selectivity profiles compared to serotonin.
- They influence reward learning, visual processing, and cerebrovascular function.
- Endogenous serotonin release leads to different neurophysiological and behavioral outcomes than those produced by psychedelics.
- Major effects of psychedelics may be understood as disruptions to serotonergic signaling.
- Some actions of psychedelics remain challenging to explain with current serotonin biology.
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