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Daily rhythms of serotonin metabolism and the expression of clock genes in suprachiasmatic nucleus of rotenone-induced Parkinson’s disease male Wistar rat model and effect of melatonin administration
Daily patterns of serotonin and body clock genes in the brain's time-keeping center in a Parkinson’s rat model and how melatonin may affect them
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Abstract
Significant decreases in serotonin-related compounds were observed, with reductions of approximately 96% in melatonin levels in a rat model of Parkinson's disease.
- The mean 24 h levels of tryptophan, 5-hydroxytryptophan, serotonin, N-acetyl serotonin, and melatonin decreased by approximately 63%, 51%, 76%, 96%, and 96%, respectively.
- Increased levels of 5-methoxy indole acetic acid, 5-methoxy tryptophol, and 5-hydroxy tryptophol suggest heightened serotonin breakdown in the Parkinson's disease model.
- The rhythmic expression of clock genes rPer1, rCry1, and rBmal1 was significantly reduced, while rPer2 levels increased by about 1.7-fold.
- Melatonin administration restored the daily rhythm phase of rPer1 in the model, indicating varying sensitivity of clock components to melatonin.
- Neuroprotective effects were observed during the dark phase in animals treated with both rotenone and melatonin.
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