The Journal of clinical psychiatrySep 1, 1994

Is there a difference in effectiveness between newer and older antidepressants for severe depression?

Psychedelic Science Weekly Brief ↗PubMed ↗

Updated Apr 3, 2026

Abstract

Most studies indicate that the efficacy of SSRIs is equivalent to that of TCAs for severe depression.

The review focused on literature comparing SSRIs and TCAs specifically for severe depression.
A limited number of studies involved severely depressed inpatients.
Findings suggest that SSRIs and TCAs may provide similar therapeutic effects for severe depression.

Simplified

BACKGROUND: Depression is classified along a spectrum of severity that may have implications for treatment. Since the newer generation of serotonin selective reuptake inhibitors (SSRIs) has, for the most part, displaced the older tricyclic antidepressants (TCAs) as first-line treatment, the efficacy of the SSRIs compared with the TCAs for severe depressions has been questioned.

METHOD: I reviewed all available English-language literature in the MEDLINE data base that compared the SSRIs with the TCAs, especially those studies on severe depression.

RESULTS: Most of the studies that explored the efficacy of the SSRIs, as compared with the TCAs, for severe depression found that these two classes of antidepressants were equivalent. Nevertheless, only a few studies actually studied severely depressed inpatients.

CONCLUSION: The data suggest that the SSRIs are just as effective as the TCAs for severe depressions.

Is there a difference in effectiveness between newer and older antidepressants for severe depression?

Abstract

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the psychedelic science brief

Abstract

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the psychedelic science brief