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Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease
How sex and APOE4 gene affect blood vessel amyloid buildup in Alzheimer's disease
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Abstract
Overall CAA scores were higher in males than females in a study of 428 autopsied brain samples from Alzheimer's disease cases.
- Carrying one or more APOE4 alleles is associated with higher overall CAA scores.
- Biochemical analysis shows significantly elevated levels of detergent-soluble and detergent-insoluble Aβ40, and insoluble apoE in individuals with severe CAA or APOE4.
- The ratio of Aβ40/Aβ42 in insoluble fractions increases in the presence of CAA or APOE4 but is negatively associated with male sex.
- Levels of insoluble Aβ40 are positively associated with levels of insoluble apoE, influenced by CAA status.
- Levels of insoluble Aβ42 correlate with apoE levels regardless of CAA status.
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