Journal of the American College of Cardiology

Semaglutide works differently in men and women with artery disease in the legs

Updated

Abstract

Of 792 participants, 195 (24.6%) were female and 597 (75.4%) were male.

  • Females with peripheral artery disease and type 2 diabetes were younger and had lower rates of smoking compared to males.
  • Geometric mean maximum walking distance at baseline was 187.3 m for females and 191.5 m for males.
  • At week 52, both sexes showed consistent improvements in maximum walking distance with semaglutide treatment.
  • Improvement in pain-free walking distance was also noted for both sexes at week 52 in favor of semaglutide.
  • Quality of life improvements related to peripheral artery disease were consistent across sexes with semaglutide treatment.

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Funding

Competing interests

Funding Support and Author Disclosures This work was supported by the trial sponsor; Novo Nordisk A/S, Denmark. Dr Verma has received payment or honoraria from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Canadian Heart Research Centre, Canadian Medical and Surgical Knowledge Translation Research Group, Eli Lilly, HLS Therapeutics, Humber River Health, Janssen, Merck, Novartis, Novo Nordisk, Pfizer, PhaseBio, S & L Solutions Event Management, Sanofi, and Sun Pharma; has served on advisory boards for Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, HLS Therapeutics, Janssen, Novartis, Novo Nordisk, and Sanofi; and his institution has received research grants from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, HLS Therapeutics, Merck, Novartis, Novo Nordisk, Pfizer, PhaseBio, and Sanofi. Dr Catarig is an employee of and owns shares in Novo Nordisk. Dr Houlind has received payment or honoraria, along with travel support, to give a presentation at a workshop organized by LeMaitre. Dr Ludvik has received consulting fees, payment, or honoraria from Amgen, Bayer, Boehringer Ingelheim, Eli Lilly, and Novo Nordisk; has received travel support from Novo Nordisk, with unpaid roles as a National Leader for the Novo Nordisk ESSENCE trial; is a National Leader for the Eli Lilly Triumph-Outcome Study; and is an advisor for an advisory board for the Austrian Obesity Society. Dr Nordanstig has received payment or honoraria from Novo Nordisk; has received travel support from Philips Medical and Abbott; has served on advisory boards for AstraZeneca, Novo Nordisk, and iThera Medical; and has a research grant from the Swedish Heart and Lung Foundation 2021–26, with unpaid roles as President of the Swedish Society for Vascular Surgery and the Swedish Councillor for the European Society for Vascular Surgery 2020–23. Dr Rasouli has served on advisory boards for Eli Lilly and Novo Nordisk; and has received research grants from Eli Lilly, Novo Nordisk, and Soma Scan. Dr Sourij has received payment or honoraria from Amarin, Amgen, Bayer, Boehringer Ingelheim, Daiichi-Sankyo, Eli Lilly, and Novo Nordisk; has received travel support from Boehringer Ingelheim, Daiichi-Sankyo, and Novo Nordisk; and has served on advisory boards for Amarin, Amgen, Daiichi-Sankyo, Novartis, Boehringer Ingelheim, Eli Lilly, and Novo Nordisk, with unpaid roles as a board member of the Austrian Diabetes Association. Dr Thomas is an employee and shareholder at Novo Nordisk. Dr Nørgaard is an employee of Novo Nordisk. Dr Bonaca is the Executive Director of the Colorado Prevention Center, a nonprofit academic research organization affiliated with the University of Colorado, that receives or has received research grant or consulting funding between August, 2021 and the present from: Abbott Laboratories, Agios Pharmaceuticals, Alexion Pharma, Alnylam Pharmaceuticals, Amgen, Angionetics, Anthos Therapeutics, Array BioPharma, AstraZeneca and Affiliates, Atentiv, Audentes Therapeutics, Bayer and Affiliates, Bristol Myers Squibb, Cambrian Biopharma, Cardiol Therapeutics, CellResearch, Cleerly, Cook Regentec, CSL Behring, Eidos Therapeutics, EP Trading, Epizon Pharma, Esperion Therapeutics, Everly Well, Exicon Consulting, Faraday Pharmaceuticals, Foresee Pharmaceuticals, Fortress Biotech, HDL Therapeutics, HeartFlow, Hummingbird Bioscience, Insmed, Ionis Pharmaceuticals, Janssen and Affiliates, Kowa Research Institute, Lexicon Pharmaceuticals, Medimmune, Merck and Affiliates, Nectero Medical, Novartis Pharmaceuticals, Novo Nordisk, Osiris Therapeutics, Pfizer, PhaseBio Pharmaceuticals, Prairie Education and Research Cooperative, Prothena Biosciences, Regeneron Pharmaceuticals, Regio Biosciences, Sanofi-Aventis Group, Silence Therapeutics, Smith & Nephew, Stealth BioTherapeutics, Tourmaline, VarmX, and Virta Health Corporation.
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