Different immune reactions to two SFTSV mRNA vaccines in mice and dogs

In mice, the Gn mRNA vaccine induced higher neutralizing antibody titers than the Gc vaccine.

• Both Gn and Gc mRNA vaccines provided complete protection against lethal SFTSV challenge in mice with a blocked immune response.
• The Gn mRNA vaccine produced stronger cellular immune responses compared to the Gc vaccine in mice.
• In dogs, the Gc mRNA vaccine generated significantly higher neutralizing antibody titers than the Gn vaccine.
• Both vaccines demonstrated comparable safety profiles in dogs.
• The differences in immune response between species highlight the need for host-specific considerations in vaccine development.

Simplified