Combined SGLT2 Inhibitor and GLP-1 Receptor Agonist Treatment Strongly Improved Kidney Function in a Type 2 Diabetes Patient, Suggesting Added Kidney Protection

At 70 years old, the patient's estimated glomerular filtration rate (eGFR) dropped below 50 mL/min/1.73 m, indicating severe kidney impairment.

• The patient had type 2 diabetes for 16 years and developed macroalbuminuria at age 64.
• Despite maintaining an HbA1c below 7%, the patient's eGFR declined rapidly.
• A renal biopsy confirmed the presence of diabetic nephropathy.
• Combination therapy with sodium glucose transporter 2 inhibitors and glucagon-like peptide-1 receptor agonists led to significant improvements in eGFR and urinary albumin levels.
• The beneficial effects on renal function persisted over a two-year period.

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