Silicon rhodamine-based fluorescent probes for monitoring mitochondrial viscosity dynamics during mitophagy

Apr 7, 2026Chemical communications (Cambridge, England)

Fluorescent probes for tracking changes in mitochondrial thickness during mitophagy

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Abstract

A silicon rhodamine (SiR)-based imaging probe was developed to monitor mitochondrial inner membrane viscosity in real-time.

  • Mitochondrial autophagy is crucial for maintaining cellular health and quality control of mitochondria.
  • Real-time visualization of mitochondrial inner membrane viscosity is important for understanding mitophagy.
  • The new imaging probe allows for reliable observation of mitophagic processes.
  • This approach offers new insights into how mitochondria are remodeled during autophagy.

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