Silver functionalized chitosan composite hydrogel with sustained silver release and enhanced antibacterial properties promotes healing of infected wounds

Dec 4, 2024International journal of biological macromolecules

Silver-coated chitosan gel that slowly releases silver and boosts antibacterial action to help heal infected wounds

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Regenerative Health on OpenScience ↗PubMed ↗DOI ↗

Abstract

The wound healing rate reached 99% by the eighth day with the Ag-functionalized chitosan hydrogel.

Bacterial infections during wound healing can delay recovery, highlighting the need for effective wound dressings.
The proposed hydrogel dressing combines silver nanoparticles and chitosan to provide antibacterial effects and promote healing.
It demonstrates excellent properties such as injectability, self-healing, and sustained release of silver over 7 days.
In a mouse model, the hydrogel significantly outperformed the control group in wound healing speed.
Hydrogel-treated wounds showed improved re-epithelialization, collagen deposition, and blood vessel formation, alongside reduced inflammation.

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Bacterial infections during wound healing often cause inflammation, which delays the healing process. Therefore, innovative wound dressings are urgently needed to inhibit bacterial infections and promote healing. This study proposes an Ag-functionalized chitosan hydrogel dressing, formed via a Schiff-base reaction between alkynyl Ag substituted chitosan (Ag-CS) and octafunctionalized polyhedral oligomeric silsesquioxane with benzaldehyde-terminated polyethylene glycol (POSS-PEG-CHO), to address the issue of bacterial infection in wounds. The hydrogel demonstrated excellent injectability and self-healing properties. AgNPs and alkynyl Ag, produced by the reducing effect of chitosan and the reversible reaction of alkynyl Ag, delay the release of Ag. Furthermore, the hydrogel exhibits a broad-spectrum antibacterial effect and effectively inhibits bacterial biofilm formation. The release of Aglasts for 7 days, ensuring sustainable antibacterial properties. In a mouse infected wound model, the composite hydrogel significantly accelerated wound healing. By the eighth day, the wound healing rate reached 99 %, whereas the control group achieved only 91 %. Histological and immunofluorescence staining results indicated that hydrogel-treated wounds had faster re-epithelialization, collagen deposition, and angiogenesis, with reduced inflammation. In conclusion, the Ag-functionalized chitosan hydrogel, with sustained Ag release and enhanced antibacterial properties, shows great potential as a wound dressing for promoting the healing of infected wounds. + +

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Silver functionalized chitosan composite hydrogel with sustained silver release and enhanced antibacterial properties promotes healing of infected wounds

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