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A single-nucleus RNA-seq dataset of the colon in Pink1-deficient and wild-type mice
Gene activity in colon cells of normal and Pink1-lacking mice
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Abstract
A single-nucleus RNA sequencing dataset was generated from gut tissue of wild-type and Pink1 knockout mice.
- Pink1 deficiency is associated with disruptions in mitophagy and gastrointestinal homeostasis.
- Altered gut-to-brain signaling mechanisms may influence neurodegenerative processes linked to Pink1 mutations.
- Major cell populations identified in the gut include goblet cells, immune cells, and colonocytes.
- Transcriptional profiles of these cell populations were characterized, providing insights into their functions.
- The dataset enables exploration of changes in cell-type composition and gene expression due to Pink1 loss.
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