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Abstract
SIRT1 activators, such as resveratrol, metformin, and statins, demonstrate neuroprotective effects against brain aging.
- Aging increases the frequency of DNA repair errors and genomic instability.
- Decreased antioxidant capacity during aging is associated with oxidative stress and DNA injury.
- Cognitive impairment and memory disorders are common manifestations of brain aging.
- Neuronal senescence is a major pathway contributing to the progression of brain aging.
- SIRT1 plays a critical role in maintaining genomic stability and is highly expressed in brain regions important for metabolism.
- Activators of SIRT1 may mitigate brain aging by influencing inflammatory and oxidative stress pathways.
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