Molecules (Basel, Switzerland)Oct 16, 2026

New Treatments Targeting Sirtuins for Healthy Thinking in Aging and Possible Benefits for Alzheimer's Disease

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Oct 21, 2026

Abstract

Sirtuins (SIRTs) are implicated in a variety of biological processes related to aging.

Specific SIRTs are downregulated during aging and in Alzheimer's disease.
Diet, exercise, and natural compounds may influence the activity of SIRTs.
Modulating SIRT function could provide new therapeutic strategies for Alzheimer's disease.
Understanding SIRTs may help in developing interventions to promote healthy cognitive aging.

Simplified

Nicotinamide adenine dinucleotide (+)-dependent class III histone deacetylases, widely known as sirtuins (SIRTs), have been found to play key functions in a wide range of biological processes implicated in ageing processes. The downregulation of some specific SIRTs was reported in ageing and in some neurological diseases such as Alzheimer's disease. SIRT modulator factors, such as diet, exercise and various natural compounds, have recently emerged as a potential new avenue of therapy to modify the progression of Alzheimer's disease and delay some ageing effects. This review synthesises recent advances in the understanding of the modulatory effects of SIRTs in the context of healthy ageing with a particular focus on cognitive function and implications for Alzheimer's disease.

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New Treatments Targeting Sirtuins for Healthy Thinking in Aging and Possible Benefits for Alzheimer's Disease

Abstract

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