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Abstract
Microbial dysbiosis in psoriatic lesions is associated with a reduction in Lactobacillus.
- Topical administration of Lactobacillus plantarum may alleviate psoriatic lesions.
- L. plantarum produces indole-3-lactic acid, which is linked to restoring circadian rhythms in skin cells.
- Restoration of circadian rhythmicity in keratinocytes could suppress ferroptosis, a form of cell death.
- Promoting epidermal barrier repair is suggested as a potential outcome of L. plantarum treatment.
Simplified
Circadian Biology