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Sleep and circadian rhythm disturbances in intensive care unit (ICU)-acquired delirium: a case–control study
Sleep and body clock problems linked to delirium in intensive care patients
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Abstract
Patients with exhibited less than 1.05% rapid eye movement (REM) sleep compared to controls.
- levels were lower and levels were higher in patients with delirium than in the control group.
- , melatonin, and cortisol levels are significantly associated with the occurrence of ICU-acquired delirium.
- Optimal cutoff values for predicting delirium included REM sleep at ≤1.05%, mean melatonin at ≤422.09 pg/mL, and cortisol at ≥212.14 ng/mL.
- Improving sleep patterns and restoring circadian rhythm may be potential therapeutic approaches for ICU-acquired delirium.
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Key numbers
≤1.05%
Decrease in
Optimal cutoff value predicting risk.
≤422.09 pg/mL
Lower Level
Optimal cutoff value predicting risk.
≥212.14 ng/mL
Higher Level
Optimal cutoff value predicting risk.