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Sleep and Cytokines: A Bidirectional Dialogue Involving Rest and Immunity
How Sleep and Immune Signals Influence Each Other
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Abstract
Sleep disorders may disrupt cytokine production and shift secretion peaks from night to day.
- Cytokines like interleukin-1β and tumor necrosis factor-α mediate the relationship between sleep and inflammation.
- Sleep deprivation can lead to increased daytime fatigue and impaired cognitive performance.
- Altered cytokine rhythms could heighten susceptibility to infections and systemic inflammation.
- Insufficient sleep may prime immune cells to trigger stronger pro-inflammatory responses.
- There is a potential feedback loop between neuroendocrine pathways and inflammatory dysregulation affecting sleep patterns.
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