Associations Between Sleep Deprivation, Circadian Gene Expression, Depressive Symptoms, and Psychomotor Performance—Preliminary Results

Feb 27, 2026Journal of clinical medicine

Links Between Sleep Loss, Body Clock Genes, Depression Signs, and Movement Skills - Early Findings

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Abstract

In non-responders to sleep deprivation, the error count in the Bimanual Eye-Hand Coordination Test positively correlated with the expression of several clock genes.

  • Sleep deprivation may influence mood and cognitive abilities, particularly psychomotor functions.
  • Seventy participants were evaluated for mood changes and psychomotor function after sleep deprivation.
  • Participants were categorized as responders or non-responders based on mood changes.
  • In non-responders, clock gene expression was associated with increased errors in psychomotor tasks.
  • The variability in psychomotor performance could be explained by clock gene expression to a significant extent.

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Full Text

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