Sleep deprivation and a non–24‐h working schedule lead to extensive alterations in physiology and behavior

Mar 8, 2019FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Sleep loss and working outside a 24-hour cycle cause widespread changes in body functions and behavior

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Abstract

Significant changes in sleepiness and cognitive performance were observed after a 10-day sleep deprivation and non-24-hour work schedule experiment.

Subjects experienced increased sleepiness despite being able to sleep during the schedule.
A 12-hour work schedule may lead to chronic sleep deprivation.
Reaction times were significantly delayed compared to the control period, as measured by the neurobehavioral psychomotor vigilance test.
Saliva insulin levels showed significant changes in the morning during sleep deprivation and non-24-hour cycles.
Salivary biochemical parameters, including aspartate aminotransferase, were altered.
Analysis of the salivary microbiota revealed different patterns in bacterial composition and concentration.

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Most organisms on Earth possess circadian rhythms in their physiology and behaviors that allow them to resonate with the cycling environment over a 24-h period. However, in human society, a substantial quantity of jobs requires non-24-h working and rest or shift schedules, which causes more or less misalignment in circadian rhythms and disorders as a consequence. In this work, we conducted a sleep deprivation (SD) and non-24-h working and rest schedule (8 h on and 4 h off) experiment over 10 d in total and measured the changes in a series of physiologic and cognitive parameters. The results show that although the subjects could sleep during the schedule, their sleepiness increased significantly. Actigraphy data suggest that a 12-h schedule might result in chronic SD. Along with the increased sleepiness revealed by the Karolinska Sleepiness Scale questionnaire, the neurobehavioral psychomotor vigilance test data reveal that, compared with the control period, the reaction time of the subjects was significantly delayed. The saliva insulin levels were significantly changed in the morning in SD and non-24-h cycles. Salivary biochemical parameters were also altered, including aspartate aminotransferase and K. 16S rRNA-based analysis of the salivary microbiota showed differentially changed patterns in bacteria composition and concentration. Together, these data demonstrate that an abnormal working and rest schedule might produce comprehensive interference with circadian rhythms, metabolism, and cognition.-Ma, H., Li, Y., Liang, H., Chen, S., Pan, S., Chang, L., Li, S., Zhang, Y., Liu, X., Xu, Y., Shao, Y., Yang, Y., Guo, J. Sleep deprivation and a non-24-h working schedule lead to extensive alterations in physiology and behavior. +

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Sleep deprivation and a non–24‐h working schedule lead to extensive alterations in physiology and behavior

Abstract

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