Effects of sleep deprivation of various durations on novelty-related object recognition memory and object location memory in mice

Sleep deprivation lasting 24 hours improved object location memory in mice, while longer durations had detrimental effects.

• 24 hours of rapid eye movement sleep deprivation (REM SD) enhanced object location memory, indicated by improved performance in recognition tasks.
• This improvement was associated with increased hippocampal synaptic plasticity, including gains in dendritic spines and higher levels of GluA1 protein.
• In contrast, 48 hours of REM SD did not influence object location memory or synaptic plasticity.
• Seventy-two hours of REM SD impaired object location memory and led to significant reductions in dendritic spines, decreased GluA1 expression, and weakened long-term potentiation.

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