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Sleep traits and breast cancer risk: a two-sample Mendelian randomization study
Sleep patterns and breast cancer risk: a genetic study using two data groups
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Abstract
Genetic analysis of sleep patterns involved n = 177,604 for morning/evening person and n = 133,384 breast cancer cases.
- Chronotype, encompassing both morning and evening types, is associated with the risk of overall breast cancer.
- Being a morning person is linked to a lower risk of breast cancer in general.
- Daytime dozing is connected to a reduced risk of breast cancer overall.
- Morning person chronotype shows a negative association with luminal B, HER2-negative-like subtypes.
- Daytime dozing is negatively correlated with luminal A-like, luminal B-like, and HER2-enriched-like subtypes.
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Key numbers
1.19
Increased Risk
Odds ratio for overall breast cancer risk associated with .
0.95
Protective Effect
Odds ratio for overall breast cancer risk in morning persons.
0.3
Lower Risk
Odds ratio for luminal A-like breast cancer risk linked to daytime dozing.