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Sleep traits causally affect epigenetic age acceleration: a Mendelian randomization study
Sleep patterns may influence the speed of biological aging
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Abstract
Self-reported insomnia may speed up the aging process by GrimAge clock.
- The study suggests a potential causal relationship between sleep disorders and aging as measured by epigenetic clocks.
- GrimAge acceleration is associated with a faint reduction in self-reported insomnia.
- Epigenetic clocks, particularly PhenoAge and GrimAge, may have weak effects on sleep traits.
- Findings indicate that early interventions for sleep disorders could influence aging and related diseases.
- Further research is needed to clarify the mechanisms linking sleep traits and aging.
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Key numbers
1.17
Increased GrimAge Acceleration
Odds ratio for self-reported insomnia's effect on GrimAge acceleration.
3.65
Higher HannumAge Association
Odds ratio for accelerometer-measured sleep efficiency's impact on HannumAge.
1.59
Increased IEAA Association
Odds ratio for accelerometer-measured number of sleep episodes on IEAA.