Self-reported insomnia may speed up the aging process by GrimAge clock.
The study suggests a potential causal relationship between sleep disorders and aging as measured by epigenetic clocks.
GrimAge acceleration is associated with a faint reduction in self-reported insomnia.
Epigenetic clocks, particularly PhenoAge and GrimAge, may have weak effects on sleep traits.
Findings indicate that early interventions for sleep disorders could influence aging and related diseases.
Further research is needed to clarify the mechanisms linking sleep traits and aging.
Simplified
Sleep disorders (SDs) are a common issue in the elderly. Epigenetic clocks based on DNA methylation (DNAm) are now considered highly accurate predictors of the aging process and are associated with age-related diseases. This study aimed to investigate the causal relationship between sleep traits and the epigenetic clock using (MR) analysis. The genome-wide association study (GWAS) statistics for epigenetic clocks (HannumAge, intrinsic [IEAA], PhenoAge, and GrimAge) and sleep traits were obtained from the UK Biobank (UKB), 23andMe and Finngen. Moreover, crucial instrumental variables (IVs) were evaluated. Inverse variance weighted (IVW), MR-Egger, weighted median (WM), weighted mode, and simple mode methods were employed to assess the causal relationship between them. Multiple analyses were performed for quality control evaluation. Our study showed that self-reported insomnia may speed up the aging process by GrimAge clock, while GrimAge acceleration could faintly reduce self-reported insomnia. Epigenetic clocks mainly influence sleep traits by PhenoAge and GrimAge with weak effects. This may indicate that early interventions of SDs could be a breaking point for aging and age-related diseases. Further studies are required to elucidate the potential mechanisms involved.
Key numbers
1.17
Increased GrimAge Acceleration
Odds ratio for self-reported insomnia's effect on GrimAge acceleration.
3.65
Higher HannumAge Association
Odds ratio for accelerometer-measured sleep efficiency's impact on HannumAge.
1.59
Increased IEAA Association
Odds ratio for accelerometer-measured number of sleep episodes on IEAA.
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