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Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease
Small molecules from gut microbes linked to changes in non-alcoholic fatty liver disease
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Abstract
Fewer than half of patients with non-alcoholic fatty liver disease (NAFLD) exhibit increased intestinal permeability.
- NAFLD includes conditions from simple fatty liver to severe liver damage like fibrosis and cancer.
- The development of NAFLD may be influenced by environmental, genetic, and metabolic factors.
- Changes in the gut microbiota and their byproducts could be linked to NAFLD progression.
- Intestinal barrier dysfunction is associated with the development of NAFLD.
- Microbial metabolites such as trimethylamine, bile acids, short-chain fatty acids, and ethanol may play significant roles in NAFLD.
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