Using SNAC to Improve How Well Medicines Are Absorbed When Taken by Mouth: An Updated Review

Medium chain fatty acids, such as sodium caprate, have been studied to enhance the oral delivery of proteins and peptides.

• Oral delivery of proteins and peptides faces significant challenges regarding bioavailability and patient compliance.
• Surfactants, fatty acids, bile salts, pH modifiers, and chelating agents have been investigated to improve intestinal absorption.
• Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC) and its derivatives may assist in overcoming these delivery obstacles.
• The review discusses the chemistry and potential toxicity of SNAC, along with mechanisms for enhancing oral delivery.
• Clinically proven molecules, like simaglutide, and others under development may benefit from these enhanced delivery methods.

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