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The SNL‐HDA19 histone deacetylase complex antagonizes HY5 activity to repress photomorphogenesis in Arabidopsis
A protein complex reduces light-driven growth by opposing a key light-activated factor in Arabidopsis plants
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Abstract
The conserved HDA19 deacetylase complex is identified as a negative regulator of the light signaling pathway.
- HDA19 and SNLs are essential for removing acetyl groups from histones, leading to chromatin inactivation of the PHYA gene.
- Light repression of HDA19 and SNL expression occurs through photoreceptor-mediated mechanisms.
- The HDA19 complex is recruited by the transcription factor HY5 to chromatin regions of light signaling genes.
- This recruitment decreases accessibility and acetylation of histones, resulting in reduced expression of HY5 and BBX22.
- HDA19, SNL1, and HY5 bind to shared regulatory regions, with HY5 binding increasing when SNL-HDA19 function is disrupted.
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