Among 13,782 women and 11,838 men aged 64 and older, was associated with a 20% lower likelihood of for women and a 14% lower likelihood for men.
Healthy aging was defined as survival to age 80 without major chronic diseases.
Among women, showed an inverse association with healthy aging only in those who were socially isolated.
Women experiencing both social isolation and loneliness had a 48% lower likelihood of healthy aging compared to those with neither condition.
This association for women remained significant after adjusting for various sociodemographic and health-related factors.
No similar joint relationship between social isolation and loneliness was observed among men.
Simplified
BACKGROUND: and have been recognized as important psychosocial factors affecting human health. We aimed to examine the relationships of social isolation and loneliness with the likelihood of among older women and men.
METHODS: The prospective study included 13,782 female and 11,838 male participants who were aged 64 years or older and had no major chronic diseases during recruitment of the UK Biobank (2006-2010). All participants were eligible to survive to age 80 before the latest follow-up (December 2021). Healthy aging was defined as survival to age 80 without major chronic diseases. Multivariable logistic regression models were used to evaluate the associations of social isolation, loneliness and their combination with the likelihood of healthy aging.
RESULTS: A total of 9130 women (58.77%) and 6406 men (41.23%) achieved healthy aging. After adjusting for age and race/ethnicity, social isolation was associated with a significantly 20% and 14% lower likelihood of healthy aging among women and men, respectively, whereas among both sexes the associations for loneliness were similar but statistically non-significant. Among women, the association between loneliness and healthy aging varied by social isolation status (P = 0.031), with an inverse association limiting to women who were socially isolated (OR = 0.61; 95% CI: 0.43-0.87). Women with both social isolation and loneliness had a 48% (OR = 0.52; 95% CI: 0.37-0.73) lower likelihood of healthy aging as compared with women with neither, and this association remained after adjusting for a wide arrange of sociodemographic, behavioral, biological, and female-specific risk factors (OR = 0.63; 95% CI: 0.44-0.90). Such a joint relationship was not observed among men. interaction
CONCLUSIONS: A coexistence of social isolation and loneliness was associated with a substantially lower likelihood of healthy aging among women. Our findings highlight the importance of social support in extending women's healthspan beyond the management of traditional risk factors.
Key numbers
20%
Lower likelihood of among women due to
Adjusted for age and race/ethnicity.
48%
Lower likelihood of among women with both conditions
Compared to women with neither condition.
14%
Lower likelihood of among men due to
Adjusted for age and race/ethnicity.
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Declarations. Ethics approval and consent to participate: The study was approved by the Northwest Multi-Centre Research Ethics Committee (REC reference for UK Biobank 11/NW/0382). All study participants provided written informed consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
