SOCS3 expression in SF1 cells regulates adrenal differentiation and exercise performance

Mice lacking the SOCS3 protein in specific brain cells demonstrated impaired training performance during resistance exercise.

• The absence of SOCS3 in steroidogenic factor-1 (SF1) cells affected the terminal differentiation of the adrenal gland.
• Adult SF1 Socs3 KO mice showed similar adrenal weight and plasma hormone levels compared to controls but had blunted hormone secretion in response to stimulation.
• Resistance training did not significantly alter metabolic responses, such as body fat and glucose tolerance, in SF1 Socs3 KO mice.
• Training performance and glucose control during intense exercise were compromised in SF1 Socs3 KO mice.
• A diminished counter-regulatory response to low glucose was noted in the mutant mice.

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