The nightly administration of sodium oxybate results in significant reduction in the nocturnal sleep disruption of patients with narcolepsy

After 8 weeks, sodium oxybate significantly increased Stage 3 and 4 sleep by 43.5 and 24.25 minutes, respectively.

• Sodium oxybate administration is associated with increased slow-wave sleep, measured by both median time in Stage 3 and 4 sleep.
• There is a significant decrease in nocturnal awakenings in patients treated with sodium oxybate.
• No significant changes in sleep parameters were observed in patients receiving placebo or modafinil alone.
• The findings suggest that sodium oxybate may effectively reduce sleep disruption in narcolepsy patients.

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