Association of soluble intercellular adhesion molecule–1 with insulin resistance and metabolic syndrome in Taiwanese

Apr 28, 2009Metabolism: clinical and experimental

Link between soluble cell adhesion molecule levels and insulin resistance with metabolic syndrome in Taiwanese people

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Abstract

Six hundred nine individuals were analyzed for associations between soluble intercellular adhesive molecule-1 (sICAM-1) levels and cardiovascular risk factors.

sICAM-1 levels were negatively associated with high-density lipoprotein cholesterol.
Positive associations were found between sICAM-1 levels and systolic, mean, and diastolic blood pressure, body mass index, waist circumference, waist-hip ratio, fasting serum insulin, triglycerides, and C-reactive protein.
Higher sICAM-1 levels were observed in current smokers, individuals with diabetes, those with insulin resistance, and those with metabolic syndrome.
sICAM-1 levels increased consistently with higher Framingham risk score quartiles and a greater number of metabolic syndrome components.
In those with metabolic syndrome, elevated C-reactive protein levels were linked to increased sICAM-1 levels.

AI simplified

Circulating concentrations of soluble cell adhesive molecules are useful predictors for the risk of development and progression of atherosclerosis. This study was initiated to investigate the association between soluble intercellular adhesive molecule-1 (sICAM-1) levels and traditional and emerging cardiovascular risk factors, as well as insulin resistance and metabolic syndrome, in a Taiwanese population. Six hundred nine unrelated individuals recruited during routine health examinations were enrolled for the analysis. In age- and sex-adjusted regression models, sICAM-1 levels were negatively associated with high-density lipoprotein cholesterol levels and positively associated with systolic, mean, and diastolic blood pressure; body mass index; waist circumference; waist-hip ratio; the homeostasis model assessment index; fasting serum insulin; triglyceride; and C-reactive protein levels. The sICAM-1 levels were also higher in subjects with current smoking (P = .001), diabetes mellitus (P = .004), insulin resistance (P < .001), and metabolic syndrome (P < .001). The sICAM-1 levels increased in a stepwise fashion with increasing Framingham risk score quartiles (P = .001) and with increasing number of metabolic syndrome components (P < .001). In subjects with metabolic syndrome, increased C-reactive protein levels were associated with increased sICAM-1 levels (P = .003). In stepwise linear regression models, sICAM-1 levels remained associated with current smoking, insulin resistance, and metabolic syndrome. In conclusion, our data revealed that insulin resistance and metabolic syndrome were associated with sICAM-1 levels in Taiwanese. These data provide further evidence of the mechanisms of sICAM-1 as a molecular marker for atherosclerosis.

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Association of soluble intercellular adhesion molecule–1 with insulin resistance and metabolic syndrome in Taiwanese

Abstract

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