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Abstract
Autophagy is a critical cellular mechanism that regulates the degradation of misfolded proteins and non-functional organelles.
- Autophagy can be classified into three major types: macroautophagy, microautophagy, and chaperone-mediated autophagy.
- Sequestosome 1 (SQSTM1)/p62 functions as a selective autophagy receptor that binds misfolded proteins for degradation.
- p62 integrates multiple signaling pathways, including those involving NF-κB, mTORC1, and NRF2.
- Phase separation of p62 is an important regulatory process within the autophagy mechanism.
- Impaired or excessive autophagy mediated by p62 is associated with cancer development.
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