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Strain specific behavioral and physiological responses to constant light in male CBA/J and CBA/CaJ mice
Strain differences in behavior and body responses to constant light in male CBA/J and CBA/CaJ mice
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Abstract
CBA/CaJ mice exhibited greater circadian period lengthening and increased weight gain when exposed to compared to CBA/J mice.
- CBA/CaJ mice showed reduced glucose levels and increased novelty-induced locomotor activity in constant light.
- Both CBA/J and CBA/CaJ mice experienced reductions in thyroid hormone and insulin levels under constant light.
- The physiological and behavioral alterations were more pronounced in CBA/CaJ mice, suggesting a link between circadian photoreceptivity and these changes.
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Key numbers
CBA/CaJ in
Increase in Active Time
CBA/CaJ mice showed increased active time in open field tests under .
CBA/CaJ vs. CBA/J
Weight Gain Comparison
CBA/CaJ mice gained weight in , while CBA/J mice did not.
TSH and fT4
Reduced Hormone Levels
Both substrains had reduced TSH and fT4 in response to .