Strength training reduces lipid accumulation in liver of obese Wistar rats

Sep 8, 2019Life sciences

Strength training lowers liver fat in obese rats

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Abstract

Strength training reduced the expression of adiposity and liver fat accumulation in Wistar rats after 12 weeks.

Strength training is associated with a decrease in glycogen and lipid accumulation in the liver.
The reduction in fat accumulation may correlate with decreased levels of proteins linked to fat breakdown and lipid production.
High fat diet consumption is linked to altered lipid production and may lead to increased fat accumulation in the liver.
Obesity-related changes in liver fat production were diminished following strength training over the study period.

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UNLABELLED: Obesity has a positive relation to non-alcoholic fatty liver disease (NAFLD) and studies have demonstrated that strength training can regulate lipid accumulation in the hepatocytes of obese rats.

AIMS: Our aim is to evaluate the effects of high fat diet and strength training on markers of oxidation and lipogenesis in the liver of Wistar rats.

MAIN METHODS: Forty Wistar rats were divided into four groups (n = 10): control (CTL), strength training (TR), high fat diet consumption (HF) and high fat diet consumption with strength training (HFT). Animals were subjected to physical strength training and high fat diet consumption for 12 weeks, 3 session per week. Then, the animals were euthanized, and liver markers were evaluated via immunolabeling.

KEY FINDINGS: Our results indicated that strength training reduced the expression of adiposity as well as the accumulation of glycogen and lipids in the liver. This reduction of fatty acid (FA) stored in hepatocytes is related to reduction of proteins linked to β-oxidation such as Fas/CD95, LIMP-II and CD36, as well as other proteins linked to lipogeneses such as SREBP-1.

SIGNIFICANCE: Finally, we observed that high fat diet can alter lipogenesis and reduce β-oxidation promoted hepatic fat accumulation. In conclusion, there was a reduction of obesity-related hepatic lipogenesis after 12 weeks of strength training.

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Strength training reduces lipid accumulation in liver of obese Wistar rats

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