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Stroke-related gut bacteria imbalance may speed up Alzheimer's disease
Updated
Abstract
Essence
In an Alzheimer's mouse model, gut microbes from stroke patients accelerated AD-like brain pathology and metabolic disruption.
Evidence
A fecal microbiota transplantation experiment transferred stool from stroke patients or healthy donors into young 3xTg-AD mice and tracked brain, gut, metabolic, and spatial transcriptomic changes.
Caveat
This is preclinical mouse-transfer evidence, so it suggests a mechanism for post-stroke AD risk rather than proving the same effect in human stroke survivors.
Simplified
Key numbers
8.7%
Increase in p-tau Levels
p-tau levels in hippocampus for stroke-FMT vs. healthy-FMT mice
0.92
Gut Microbiome Diversity
Simpson index for stroke donors vs. healthy donors
0.48
Increase in Metabolites
Pyruvate levels in cecal contents of stroke-FMT mice
Gut-Brain Axis