Journal of affective disordersOct 22, 2026

Suicidal thoughts and behaviors during treatment with nasal esketamine: A look back at patient records

Psychedelic Science Weekly Brief ↗PubMed ↗DOI ↗

Updated Oct 23, 2026

Abstract

Intranasal (es)ketamine is effective in treating treatment-resistant depression (TRD).

The impact of intranasal (es)ketamine on suicidality remains unclear.
Further investigation is needed to understand its effects on suicidal thoughts.
Current evidence supports its use primarily for alleviating depressive symptoms.

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