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Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections
Mouse brain’s internal clock: eye input, internal structure, and output pathways
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Abstract
The mouse suprachiasmatic nucleus (SCN) exhibits distinct subdivisions with specialized neurotransmitter profiles and connections.
- The SCN is divided into core and shell subdivisions, each with unique chemical markers and connections.
- Neurons in the SCN shell produce GABA, calbindin, arginine vasopressin, angiotensin II, and met-enkephalin.
- The SCN shell receives inputs from fibers containing galanin and vasoactive intestinal polypeptide.
- Neurons in the SCN core synthesize GABA, calbindin, vasoactive intestinal polypeptide, calretinin, gastrin releasing peptide, and neurotensin.
- The SCN core receives input from the retina and fibers that contain neuropeptide Y and serotonin.
- The overall organization and connections of the mouse SCN resemble those found in other mammalian species.
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