Full text is available at the source.
Abstract
Complete tumor elimination was achieved within 7-10 days after administration of survivin mRNA lipid nanoparticles in a murine oral cancer model.
- Survivin mRNA lipid nanoparticles induced significant immune reprogramming, leading to enhanced activation of immune cells, including dendritic cells and T cells.
- A broad, multi-compartmental T-cell immune response was observed following survivin mRNA-LNP treatment compared to control.
- Significantly greater expansion of CD4+ and CD8+ T cells was noted in lymph nodes by day 3 and robust infiltration into the tumor microenvironment by day 14.
- Survivin mRNA-LNPs promoted T cell activation and increased cytotoxic CD8+Granzyme B+ T cells in the tumor microenvironment.
- Controlled Treg levels were maintained, resulting in a favorable effector to Treg ratio that is critical for effective anti-tumor responses.
- Tumor rechallenge showed the development of immunological memory against oral cancer cells.
Simplified