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Synaptic potentiation and rapid antidepressant response to ketamine in treatment-resistant major depression: A replication study
Stronger brain connections linked to fast antidepressant effects of ketamine in hard-to-treat depression: A replication study
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Abstract
A significant difference in peak gamma power was observed between depressed ketamine responders and non-responders.
- Ketamine has been shown to have rapid antidepressant effects in both preclinical and clinical studies.
- Enhancing AMPA throughput may be crucial to the effects of ketamine, as indicated by studies using AMPA inhibitors.
- Increased gamma response to a somatosensory stimulus was measured at 230 minutes and Day 1 in ketamine responders compared to non-responders.
- Findings from 31 depressed subjects and 25 healthy controls support the idea that AMPA throughput is involved in ketamine's antidepressant mechanism.
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