Psychiatry research. Neuroimaging

Stronger brain connections linked to fast antidepressant effects of ketamine in hard-to-treat depression: A replication study

Psychedelic Science Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

A significant difference in peak gamma power was observed between depressed ketamine responders and non-responders.

  • Ketamine has been shown to have rapid antidepressant effects in both preclinical and clinical studies.
  • Enhancing AMPA throughput may be crucial to the effects of ketamine, as indicated by studies using AMPA inhibitors.
  • Increased gamma response to a somatosensory stimulus was measured at 230 minutes and Day 1 in ketamine responders compared to non-responders.
  • Findings from 31 depressed subjects and 25 healthy controls support the idea that AMPA throughput is involved in ketamine's antidepressant mechanism.

Simplified

Full Text

Full text is available at the source.
View Full Text ↗

Funding

Competing interests

Declaration of interest. All other authors have no conflict of interest to disclose, financial or otherwise.
PubMed

Related papers

Dec '14
Ketamine's antidepressant effects last at least four weeks in people with a family history of alcohol use disorder
top 10% journal
cited by 27 papers
randomized controlled trial
Jul '14
Ketamine use in depression: a review and combined analysis of studies
top 20% journal
cited by 281 papers
systematic review
Jan '14
Ketamine's effects, limits, and possible working methods in mood disorders
top 5% journal
cited by 145 papers
research support, non-u.s. gov't
Oct '14
Ketamine's effectiveness in depression with and without bipolar disorder
top 20% journal
cited by 5 papers
research support, non-u.s. gov't

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the psychedelic science brief

issue #50
Psilocybin beat placebo on depression scores in an NHS trial — by a lot
6 days ago7 studies
issue #49
Psilocybin stays active in neurons long after it leaves the bloodstream — here's what that means
1 week ago7 studies
issue #48
Psychedelics during adolescence reshaped adult social behavior in rats — here's the circuit
2 weeks ago7 studies
issue #47
Psilocybin rewired prefrontal circuits in mice — but only for one specific type of cognitive failure
3 weeks ago7 studies
issue #46
Psilocybin cut two specific brain chemicals in depressed patients — here's what that means
4 weeks ago7 studies
issue #44
Psilocybin rewires brain feedback circuits for weeks after a single dose, new evidence shows
5 weeks ago7 studies
issue #43
A pill form of ketamine cut dissociation to near-zero vs. nasal spray's 29.6-point spike — but missed its main antidepressant target
6 weeks ago7 studies
issue #42
At-home ketamine injections cut depression scores by more than half in 3,870 patients
7 weeks ago8 studies
issue #41
Psychedelics disrupt brain signal flow in both humans and mice across LSD, psilocybin, and MDMA
8 weeks ago7 studies
issue #40
Inhaled 5-MeO-DMT cut postpartum depression scores by 35 points
9 weeks ago7 studies
explore the archive
See more issues from the psychedelic science brief