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Evaluation of synthetic 2-aryl quinoxaline derivatives as α-amylase, α-glucosidase, acetylcholinesterase, and butyrylcholinesterase inhibitors
Testing synthetic 2-aryl quinoxaline compounds as inhibitors of enzymes that break down sugars and nerve signals
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Abstract
Compound 14 demonstrated superior inhibitory potential with IC values of 294.35 nM for α-amylase and 17.04 nM for acetylcholinesterase.
- A series of 2-aryl quinoxaline derivatives (1-23) were synthesized and characterized.
- These compounds showed enhanced inhibition against α-amylase, α-glucosidase, acetylcholinesterase, and butyrylcholinesterase at nanomolar concentrations.
- Notably, compound 14 exhibited the strongest inhibitory effects among the derivatives tested.
- Molecular docking studies were performed on selected potent compounds to analyze their binding energies with the target enzymes.
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