A case of a whole-body allergic reaction to the diabetes drug tirzepatide

A 67-year-old woman experienced severe allergic reactions after her first dose of tirzepatide, leading to symptoms such as pruritus and urticaria.

• Severe disseminated itching and a widespread rash occurred following the initial administration of tirzepatide.
• The allergic reaction was alleviated with antihistamines, suggesting a hypersensitivity response.
• The case may indicate the potential for immunoglobulin E-mediated hypersensitivity to tirzepatide.
• Increased awareness is necessary regarding allergic reactions to new diabetes medications, especially GIP/GLP-1 receptor agonists.

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