T-Cell Senescence in Human Metabolic Diseases

Immunosenescence is characterized by a range of immune cell dysfunctions, including telomere shortening and increased inflammation.

• Immunosenescence involves several factors, such as halted cell division and mitochondrial dysfunction.
• This phenomenon is primarily observed during aging but can also arise from chronic infections and metabolic conditions.
• T-cells are particularly vulnerable to immunosenescence, which is linked to diseases like obesity and diabetes.
• Recent findings indicate a connection between T-cell senescence, inflammation, and insulin resistance.
• Senescent T-cells may play a significant role in the development of metabolic diseases through their inflammatory effects.

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