Tailor-made amino acid-derived pharmaceuticals approved by the FDA in 2019

Sep 4, 2020Amino acids

FDA-Approved Amino Acid-Based Medicines from 2019

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Abstract

13 out of 24 small-molecule drugs approved by the FDA in 2019 contain amino acids or similar compounds.

Amino acids play a crucial role in the origin and evolution of life.
Medicinal chemistry research is focused on developing more selective and potent pharmaceuticals using tailor-made amino acids.
Peptides and peptidomimetics are increasingly recognized as effective drug candidates.
The review profiles 13 newly introduced amino acid-derived pharmaceuticals from 2019.
Discussion includes drug development, total synthesis, core amino acids, therapeutic areas, and biological activity.

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Amino acids (AAs) are among a handful of paramount classes of compounds innately involved in the origin and evolution of all known life-forms. Along with basic scientific explorations, the major goal of medicinal chemistry research in the area of tailor-made AAs is the development of more selective and potent pharmaceuticals. The growing acceptance of peptides and peptidomimetics as drugs clearly indicates that AA-based molecules become the most successful structural motif in the modern drug design. In fact, among 24 small-molecule drugs approved by FDA in 2019, 13 of them contain a residue of AA or di-amines or amino-alcohols, which are commonly considered to be derived from the parent AAs. In the present review article, we profile 13 new tailor-made AA-derived pharmaceuticals introduced to the market in 2019. Where it is possible, we will discuss the development form drug-candidates, total synthesis, with emphasis on the core-AA, therapeutic area, and the mode of biological activity.

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Tailor-made amino acid-derived pharmaceuticals approved by the FDA in 2019

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