Full text is available at the source.
The targeted delivery of cancer drugs across the blood–brain barrier: chemical modifications of drugs or drug-nanoparticles?
Targeting cancer drugs across the blood-brain barrier using chemical changes or drug nanoparticles
AI simplified
Abstract
Efforts to improve drug delivery across the blood-brain barrier (BBB) are focused on chemically modifying drugs and nanoparticles.
- The blood-brain barrier poses significant challenges for drug distribution to the central nervous system.
- Research is centered on developing chemically modified drugs and nanoparticulate vectors to enhance BBB penetration.
- Chemical functionalization of drugs and drug delivery systems is being explored as a strategy to overcome biological barriers.
- Endogenous transporters at the BBB may play a role in facilitating drug delivery.
AI simplified