Recent advances in targeted drug delivery for the treatment of glioblastoma

Apr 12, 2024Nanoscale

New methods for delivering drugs directly to treat brain cancer

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Abstract

Swimming nanorobots show great potential in active targeted delivery of drugs for glioblastoma multiforme (GBM).

GBM is characterized by significant morbidity and mortality, making effective treatment challenging.
The blood-brain barrier and blood-brain tumor barrier hinder drug uptake by GBM, limiting therapeutic options.
Recent advancements in nanotechnology offer unconventional drug delivery approaches for GBM treatment.
Nanorobots can navigate biological barriers more effectively, enhancing targeted drug delivery strategies.
Current challenges in translating these technologies into clinical practice are acknowledged.

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Glioblastoma multiforme (GBM) is one of the highly malignant brain tumors characterized by significant morbidity and mortality. Despite the recent advancements in the treatment of GBM, major challenges persist in achieving controlled drug delivery to tumors. The management of GBM poses considerable difficulties primarily due to unresolved issues in the blood-brain barrier (BBB)/blood-brain tumor barrier (BBTB) and GBM microenvironment. These factors limit the uptake of anti-cancer drugs by the tumor, thus limiting the therapeutic options. Current breakthroughs in nanotechnology provide new prospects concerning unconventional drug delivery approaches for GBM treatment. Specifically, swimming nanorobots show great potential in active targeted delivery, owing to their autonomous propulsion and improved navigation capacities across biological barriers, which further facilitate the development of GBM-targeted strategies. This review presents an overview of technological progress in different drug administration methods for GBM. Additionally, the limitations in clinical translation and future research prospects in this field are also discussed. This review aims to provide a comprehensive guideline for researchers and offer perspectives on further development of new drug delivery therapies to combat GBM.

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Recent advances in targeted drug delivery for the treatment of glioblastoma

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