A DNA-based aging clock linked to death risk as a possible marker for frailty

Declarations. Ethics approval and consent to participate: The Ethics Committee of Ulm University had approved the ActiFE study and this research (application no. 318/08 and 50/12) and all participants gave written consent. For the training set, we used some blood samples from the central biobank of the medical faculty of RWTH Aachen University, which was specifically approved by the Ethics Committee of RWTH Aachen Medical School (ethics approval number EK 206/09) and all participants provided written consent. Consent for publication: Not applicable. Competing interests: W. W. is a cofounder of Cygenia GmbH, which can provide services for various epigenetic signatures, including epigenetic clocks ( www.cygenia.com ). J.-F. P.-C. contributes to Cygenia, too. Apart from this, the authors have no competing interests.